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Titel:

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Zawada, Dorota; Kornherr, Jessica; Meier, Anna B; Santamaria, Gianluca; Dorn, Tatjana; Nowak-Imialek, Monika; Ortmann, Daniel; Zhang, Fangfang; Lachmann, Mark; Dreßen, Martina; Ortiz, Mariaestela; Mascetti, Victoria L; Harmer, Stephen C; Nobles, Muriel; Tinker, Andrew; De Angelis, Maria Teresa; Pedersen, Roger A; Grote, Phillip; Laugwitz, Karl-Ludwig; Moretti, Alessandra; Goedel, Alexander
Abstract:
Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor populations. Understanding the specification and differentiation of these distinct progenitor pools during human embryonic development is crucial for advancing our knowledge of congenital cardiac malformations and designing new regenerative therapies. By combining genetic labelling, single-cell transcriptomics, and ex vivo human-mouse embryonic chimeras we uncovered that modulation of retinoic acid signaling i...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2023
Band / Volume:
14
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-023-36764-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37012244
Print-ISSN:
2041-1723
TUM Einrichtung:
Klinik für Herz- und Gefäßchirurgie (DHM) (Prof. Lange); Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz); Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
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