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Title:

Association between Platelet Count and Treatment Effect of Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes.

Document type:
Article; Randomized Controlled Trial; Journal Article
Author(s):
Koch, Tobias; Lahu, Shqipdona; Coughlan, J J; Cassese, Salvatore; Voll, Felix; Ndrepepa, Gjin; Menichelli, Maurizio; Valina, Christian; Hemetsberger, Rayyan; Witzenbichler, Bernhard; Bernlochner, Isabell; Joner, Michael; Xhepa, Erion; Mayer, Katharina; Kessler, Thorsten; Laugwitz, Karl-Ludwig; Richardt, Gert; Schunkert, Heribert; Angiolillo, Dominick J; Sibbing, Dirk; Kastrati, Adnan; Kufner, Sebastian
Abstract:
BACKGROUND:  The relative efficacy and safety of ticagrelor and prasugrel based dual antiplatelet therapy strategies according to the platelet count (PC) in patients with acute coronary syndromes (ACS) have not been defined. METHODS:  This is a posthoc analysis of the ISAR-REACT 5 trial, in which patients presenting with ACS were randomized to treatment with ticagrelor versus prasugrel. Patients were divided into quartiles according to PC. The primary endpoint was incidence of death, myocardial...     »
Journal title abbreviation:
Thromb Haemost
Year:
2023
Journal volume:
123
Journal issue:
4
Pages contribution:
464-477
Fulltext / DOI:
doi:10.1055/a-1988-5047
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36442805
Print-ISSN:
0340-6245
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert); Klinik und Poliklinik für Innere Medizin I, Kardiologie
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