Electroanatomical Conduction Characteristics of Pig Myocardial Tissue Derived from High-Density Mapping.

Wilhelm, Theresa Isabelle; Lewalter, Thorsten; Fischer, Johannes; Reiser, Judith; Werner, Julia; Baumgartner, Christine; Gleirscher, Lukas; Hoppmann, Petra; Kupatt, Christian; Tiemann, Klaus; Jilek, Clemens

doi:10.3390/jcm12175598

2023

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Title:: Electroanatomical Conduction Characteristics of Pig Myocardial Tissue Derived from High-Density Mapping.
Document type:: Journal Article
Author(s):: Wilhelm, Theresa Isabelle; Lewalter, Thorsten; Fischer, Johannes; Reiser, Judith; Werner, Julia; Baumgartner, Christine; Gleirscher, Lukas; Hoppmann, Petra; Kupatt, Christian; Tiemann, Klaus; Jilek, Clemens
Abstract:: BACKGROUND: Ultra-high-density mapping systems allow more precise measurement of the heart chambers at corresponding conduction velocities (CVs) and voltage amplitudes (VAs). Our aim for this study was to define and compare a basic value set for unipolar CV and VA in all four heart chambers and their separate walls in healthy, juvenile porcine hearts using ultra-high-density mapping. METHODS: We used the Rhythmia Mapping System to create electroanatomical maps of four pig hearts in sinus rhythm. CVs and VAs were calculated for chambers and wall segments with overlapping circular areas (radius of 5 mm). RESULTS: We analysed 21 maps with a resolution of 1.4 points/mm2. CVs were highest in the left atrium (LA), followed by the left ventricle (LV), right ventricle (RV), and right atrium (RA). As for VA, LV was highest, followed by RV, LA, and RA. The left chambers had a higher overall CV and VA than the right. Within the chambers, CV varied more in the right than in the left chambers, and VA varied in the ventricles but not in the atria. There was a slightly positive correlation between CVs and VAs at velocity values of <1.5 m/s. CONCLUSIONS: In healthy porcine hearts, the left chambers showed higher VAs and CVs than the right. CV differs mainly within the right chambers and VA differs only within the ventricles. A slightly positive linear correlation was found between slow CVs and low VAs.
Journal title abbreviation:: J Clin Med
Year:: 2023
Journal volume:: 12
Journal issue:: 17
Fulltext / DOI:: doi:10.3390/jcm12175598
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/37685665
TUM Institution:: Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)2023