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Title:

Designer pigs for xenogeneic heart transplantation and beyond.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Wolf, Eckhard; Reichart, Bruno; Moretti, Alessandra; Laugwitz, Karl-Ludwig
Abstract:
The 2-month-survival of a terminally ill patient who received a genetically modified pig heart has demonstrated that cardiac xenotransplantation could provide a therapeutic option for patients who cannot receive a human organ. Genetic engineering to overcome transplant rejection mechanisms, coagulation dysregulation and overgrowth of xeno-hearts has been the key to this success. The concept of exogenesis - the replacement of specific cellular populations and tissue structures of a pig heart with...     »
Journal title abbreviation:
Dis Model Mech
Year:
2023
Journal volume:
16
Journal issue:
5
Fulltext / DOI:
doi:10.1242/dmm.050177
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37249503
Print-ISSN:
1754-8403
TUM Institution:
Klinik und Poliklinik für Innere Medizin I, Kardiologie; Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
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