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- Dokumenttyp:
- Article; Multicenter Study; Journal Article
- Autor(en):
- Mansour, Nabeel; Nekolla, Stephan G; Reyes, Eliana; Angelidis, George; Georgoulias, Panagiotis; Anagnostopoulos, Constantinos; Bravo, Paco; Bruno, Isabella; Flotats, Albert; Fuentes-Ocampo, Francisco; Sciagrà, Roberto; Keng, Felix; Kessler, Lukas; Papathanasiou, Maria; Soman, Prem; Rischpler, Christoph
- Titel:
- Multi-center study of inter-rater reproducibility, image quality, and diagnostic accuracy of CZT versus conventional SPECT myocardial perfusion imaging.
- Abstract:
- BACKGROUND: Cadmium-zinc-telluride (CZT)-based detectors exhibit higher diagnostic sensitivity in myocardial perfusion imaging (MPI) than conventional Anger-MPI for detection of coronary artery disease (CAD); however, reduced specificity and diagnostic accuracy of CZT-MPI were observed. This study aims to compare these different camera systems and to examine the degree of inter-rater reproducibility among readers with varying experience in MPI. METHODS: 83 patients who underwent double stress/rest examinations using both a CZT and conventional SPECT cameras within one visit were included. Anonymized and randomized MPI-images were distributed to 15 international readers using a standardized questionnaire. Subsequent coronary angiography findings of ten patients served as a reference for analysis of sensitivity and specificity. RESULTS: Image quality was significantly better in CZT-MPI with significantly lower breast attenuation (P < 0.05). CZT-MPI exhibited higher sensitivity than Anger-MPI (87.5% vs. 62.5%) and significantly reduced specificity (40% vs. 100%). Readers experienced with both camera systems had the highest inter-rater agreement indicating higher reproducibility (CZT 0.54 vs. conv. 0.49, P < 0.05). CONCLUSIONS: Higher diagnostic sensitivity of CZT-MPI offers advantages in detection of CAD yet potentially of at the cost of reduced specificity, therefore it requires special training and a differentiated evaluation approach, especially for non-experienced readers with such camera systems.
- Zeitschriftentitel:
- J Nucl Cardiol
- Jahr:
- 2023
- Band / Volume:
- 30
- Heft / Issue:
- 2
- Seitenangaben Beitrag:
- 528-539
- Volltext / DOI:
- doi:10.1007/s12350-022-03054-w
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/35799039
- Print-ISSN:
- 1071-3581
- TUM Einrichtung:
- 1413; 595; Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)
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