Multi-center study of inter-rater reproducibility, image quality, and diagnostic accuracy of CZT versus conventional SPECT myocardial perfusion imaging.

Mansour, Nabeel; Nekolla, Stephan G; Reyes, Eliana; Angelidis, George; Georgoulias, Panagiotis; Anagnostopoulos, Constantinos; Bravo, Paco; Bruno, Isabella; Flotats, Albert; Fuentes-Ocampo, Francisco; Sciagrà, Roberto; Keng, Felix; Kessler, Lukas; Papathanasiou, Maria; Soman, Prem; Rischpler, Christoph

doi:10.1007/s12350-022-03054-w

journal article

Titel:: Multi-center study of inter-rater reproducibility, image quality, and diagnostic accuracy of CZT versus conventional SPECT myocardial perfusion imaging.
Dokumenttyp:: Article; Multicenter Study; Journal Article
Autor(en):: Mansour, Nabeel; Nekolla, Stephan G; Reyes, Eliana; Angelidis, George; Georgoulias, Panagiotis; Anagnostopoulos, Constantinos; Bravo, Paco; Bruno, Isabella; Flotats, Albert; Fuentes-Ocampo, Francisco; Sciagrà, Roberto; Keng, Felix; Kessler, Lukas; Papathanasiou, Maria; Soman, Prem; Rischpler, Christoph
Abstract:: BACKGROUND: Cadmium-zinc-telluride (CZT)-based detectors exhibit higher diagnostic sensitivity in myocardial perfusion imaging (MPI) than conventional Anger-MPI for detection of coronary artery disease (CAD); however, reduced specificity and diagnostic accuracy of CZT-MPI were observed. This study aims to compare these different camera systems and to examine the degree of inter-rater reproducibility among readers with varying experience in MPI. METHODS: 83 patients who underwent double stress/rest examinations using both a CZT and conventional SPECT cameras within one visit were included. Anonymized and randomized MPI-images were distributed to 15 international readers using a standardized questionnaire. Subsequent coronary angiography findings of ten patients served as a reference for analysis of sensitivity and specificity. RESULTS: Image quality was significantly better in CZT-MPI with significantly lower breast attenuation (P < 0.05). CZT-MPI exhibited higher sensitivity than Anger-MPI (87.5% vs. 62.5%) and significantly reduced specificity (40% vs. 100%). Readers experienced with both camera systems had the highest inter-rater agreement indicating higher reproducibility (CZT 0.54 vs. conv. 0.49, P < 0.05). CONCLUSIONS: Higher diagnostic sensitivity of CZT-MPI offers advantages in detection of CAD yet potentially of at the cost of reduced specificity, therefore it requires special training and a differentiated evaluation approach, especially for non-experienced readers with such camera systems.
Zeitschriftentitel:: J Nucl Cardiol
Jahr:: 2023
Band / Volume:: 30
Heft / Issue:: 2
Seitenangaben Beitrag:: 528-539
Volltext / DOI:: doi:10.1007/s12350-022-03054-w
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/35799039
Print-ISSN:: 1071-3581
TUM Einrichtung:: 1413; 595; Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)2023

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