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Titel:

Pembrolizumab and trastuzumab in combination with FLOT in the perioperative treatment of HER2-positive, localized esophagogastric adenocarcinoma-a phase II trial of the AIO study group (AIO STO 0321).

Dokumenttyp:
Article; Journal Article
Autor(en):
Tintelnot, Joseph; Stein, Alexander; Al-Batran, Salah-Eddin; Ettrich, Thomas; Götze, Thorsten; Grün, Barbara; Haag, Georg Martin; Heuer, Vera; Hofheinz, Ralf-Dieter; Homann, Nils; Bröring, Tobias Sebastian; Cruz, Mariana Santos; Kurreck, Annika; Lorenzen, Sylvie; Moosmann, Nicolas; Müller, Christian; Schuler, Markus; Siegler, Gabriele; Binder, Mascha; Gökkurt, Eray
Abstract:
BACKGROUND: Esophagogastric adenocarcinoma (EGA) presents a substantial global health challenge as the number of cases continues to rise. The current standard approach for treating localized EGA involves a combination of triplet chemotherapy, which consists of a platinum compound, a fluoropyrimidine, and a taxane (known as FLOT), followed by surgery. In cases of metastatic EGA with HER2-positive status or in certain studies with localized EGA, the use of HER2-targeted antibodies such as trastuzu...     »
Zeitschriftentitel:
Front Oncol
Jahr:
2023
Band / Volume:
13
Volltext / DOI:
doi:10.3389/fonc.2023.1272175
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37909020
Print-ISSN:
2234-943X
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann)
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