Multi-center study of inter-rater reproducibility, image quality, and diagnostic accuracy of CZT versus conventional SPECT myocardial perfusion imaging.

Mansour, Nabeel; Nekolla, Stephan G; Reyes, Eliana; Angelidis, George; Georgoulias, Panagiotis; Anagnostopoulos, Constantinos; Bravo, Paco; Bruno, Isabella; Flotats, Albert; Fuentes-Ocampo, Francisco; Sciagrà, Roberto; Keng, Felix; Kessler, Lukas; Papathanasiou, Maria; Soman, Prem; Rischpler, Christoph

doi:10.1007/s12350-022-03054-w

2023

Zurück
Zurück zum Anfang der Trefferliste
Dauerhafter Link zum angezeigten Objekt

Titel:: Multi-center study of inter-rater reproducibility, image quality, and diagnostic accuracy of CZT versus conventional SPECT myocardial perfusion imaging.
Dokumenttyp:: Article; Multicenter Study; Journal Article
Autor(en):: Mansour, Nabeel; Nekolla, Stephan G; Reyes, Eliana; Angelidis, George; Georgoulias, Panagiotis; Anagnostopoulos, Constantinos; Bravo, Paco; Bruno, Isabella; Flotats, Albert; Fuentes-Ocampo, Francisco; Sciagrà, Roberto; Keng, Felix; Kessler, Lukas; Papathanasiou, Maria; Soman, Prem; Rischpler, Christoph
Abstract:: BACKGROUND: Cadmium-zinc-telluride (CZT)-based detectors exhibit higher diagnostic sensitivity in myocardial perfusion imaging (MPI) than conventional Anger-MPI for detection of coronary artery disease (CAD); however, reduced specificity and diagnostic accuracy of CZT-MPI were observed. This study aims to compare these different camera systems and to examine the degree of inter-rater reproducibility among readers with varying experience in MPI. METHODS: 83 patients who underwent double stress/rest examinations using both a CZT and conventional SPECT cameras within one visit were included. Anonymized and randomized MPI-images were distributed to 15 international readers using a standardized questionnaire. Subsequent coronary angiography findings of ten patients served as a reference for analysis of sensitivity and specificity. RESULTS: Image quality was significantly better in CZT-MPI with significantly lower breast attenuation (P < 0.05). CZT-MPI exhibited higher sensitivity than Anger-MPI (87.5% vs. 62.5%) and significantly reduced specificity (40% vs. 100%). Readers experienced with both camera systems had the highest inter-rater agreement indicating higher reproducibility (CZT 0.54 vs. conv. 0.49, P < 0.05). CONCLUSIONS: Higher diagnostic sensitivity of CZT-MPI offers advantages in detection of CAD yet potentially of at the cost of reduced specificity, therefore it requires special training and a differentiated evaluation approach, especially for non-experienced readers with such camera systems.
Zeitschriftentitel:: J Nucl Cardiol
Jahr:: 2023
Band / Volume:: 30
Heft / Issue:: 2
Seitenangaben Beitrag:: 528-539
Volltext / DOI:: doi:10.1007/s12350-022-03054-w
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/35799039
Print-ISSN:: 1071-3581
TUM Einrichtung:: 1413; 595; Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)
BibTeX

Vorkommen:

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)2023