Extensive 177Lu-PSMA Radioligand Therapy Can Lead to Radiation Nephropathy with a Renal Thrombotic Microangiopathy-like Picture.

Schäfer, Hannah; Mayr, Sarah; Büttner-Herold, Maike; Knorr, Karina; Steinhelfer, Lisa; Böger, Carsten A; Gschwend, Jürgen E; Heemann, Uwe; Eiber, Matthias; Schmaderer, Christoph; Tauber, Robert

doi:10.1016/j.eururo.2022.05.025

2023

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Title:: Extensive 177Lu-PSMA Radioligand Therapy Can Lead to Radiation Nephropathy with a Renal Thrombotic Microangiopathy-like Picture.
Document type:: Case Reports
Author(s):: Schäfer, Hannah; Mayr, Sarah; Büttner-Herold, Maike; Knorr, Karina; Steinhelfer, Lisa; Böger, Carsten A; Gschwend, Jürgen E; Heemann, Uwe; Eiber, Matthias; Schmaderer, Christoph; Tauber, Robert
Abstract:: Lutetium-177 prostate-specific membrane antigen (177Lu-PSMA) radioligand therapy is an option that is increasingly being used for treatment of metastatic castration-resistant prostate cancer. This delivers β-radiation to cells expressing PSMA and high accumulation of the radiopharmaceutical occurs in the kidneys. Here we report three cases of radiation nephropathy with severe chronic kidney disease induced by renal thrombotic microangiopathy following extensive treatment with 177Lu-PSMA radioligand therapy. «
Lutetium-177 prostate-specific membrane antigen (177Lu-PSMA) radioligand therapy is an option that is increasingly being used for treatment of metastatic castration-resistant prostate cancer. This delivers β-radiation to cells expressing PSMA and high accumulation of the radiopharmaceutical occurs in the kidneys. Here we report three cases of radiation nephropathy with severe chronic kidney disease induced by renal thrombotic microangiopathy following extensive treatment with 177Lu-PSMA radiolig... »
Journal title abbreviation:: Eur Urol
Year:: 2023
Journal volume:: 83
Journal issue:: 5
Pages contribution:: 385-390
Fulltext / DOI:: doi:10.1016/j.eururo.2022.05.025
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/35688660
Print-ISSN:: 0302-2838
TUM Institution:: Klinik und Poliklinik für Nuklearmedizin (Prof. Weber); Klinik und Poliklinik für Urologie (Prof. Gschwend); Professur für Nephrologie (Prof. Heemann)
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