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Titel:

Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study).

Dokumenttyp:
Article; Multicenter Study; Journal Article
Autor(en):
Huemmert, Martin W.; Stern, Carlotta; Paul, Friedemann; Duchow, Ankelien; Bellmann-Strobl, Judith; Ayzenberg, Ilya; Schwake, Carolin; Kleiter, Ingo; Hellwig, Kerstin; Jarius, Sven; Wildemann, Brigitte; Senel, Makbule; Berthele, Achim; Giglhuber, Katrin; Luessi, Felix; Grothe, Matthias; Klotz, Luisa; Schuelke, Rasmus; Gingele, Stefan; Faiss, Jurgen H.; Walter, Annette; Warnke, Clemens; Then Bergh, Florian; Aktas, Orhan; Ringelstein, Marius; Stellmann, Jan-Patrick; Haeussler, Vivien; Havla, Joachi...     »
Abstract:
BACKGROUND: There is limited and inconsistent information on the prevalence of cognitive impairment in neuromyelitis optica spectrum disorders (NMOSD). OBJECTIVE: To assess cognitive performance and changes over time in NMOSD. METHODS: This study included data from 217 aquaporin-4-IgG-seropositive (80%) and double-seronegative NMOSD patients. Cognitive functions measured by Symbol Digit Modalities Test (SDMT), Paced Auditory Serial-Addition Task (PASAT), and/or Multiple Sclerosis Inventory Cognition (MuSIC) were standardized against normative data (N = 157). Intraindividual cognitive performance at 1- and 2-year follow-up was analyzed. Cognitive test scores were correlated with demographic and clinical variables and assessed with a multiple linear regression model. RESULTS: NMOSD patients were impaired in SDMT (p = 0.007), MuSIC semantic fluency (p < 0.001), and MuSIC congruent speed (p < 0.001). No significant cognitive deterioration was found at follow-up. SDMT scores were related to motor and visual disability (pBon < 0.05). No differences were found between aquaporin-4-IgG-seropositive and double-seronegative NMOSD. CONCLUSIONS: A subset of NMOSD patients shows impairment in visual processing speed and in semantic fluency regardless of serostatus, without noticeable changes during a 2-year observation period. Neuropsychological measurements should be adapted to physical and visual disabilities.
Zeitschriftentitel:
Mult Scler
Jahr:
2023
Band / Volume:
29
Heft / Issue:
7
Seitenangaben Beitrag:
819-831
Volltext / DOI:
doi:10.1177/13524585231151212
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36786424
Print-ISSN:
1352-4585
TUM Einrichtung:
1132; 1533; 303; Klinik und Poliklinik für Neurologie (Prof. Hemmer)
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