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Title:

GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications.

Document type:
Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Author(s):
Campbell, Jonathan E; Müller, Timo D; Finan, Brian; DiMarchi, Richard D; Tschöp, Matthias H; D'Alessio, David A
Abstract:
The incretin system is an essential metabolic axis that regulates postprandial metabolism. The two incretin peptides that enable this effect are the glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide 1 (GLP-1), which have cognate receptors (GIPR and GLP-1R) on islet β cells as well as in other tissues. Pharmacologic engagement of the GLP-1R is a proven strategy for treating hyperglycemia in diabetes and reducing body weight. Tirzepatide is the first monomeric peptid...     »
Journal title abbreviation:
Cell Metab
Year:
2023
Journal volume:
35
Journal issue:
9
Pages contribution:
1519-1529
Fulltext / DOI:
doi:10.1016/j.cmet.2023.07.010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37591245
Print-ISSN:
1550-4131
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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