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Title:

Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis.

Document type:
Journal Article
Author(s):
Alkhoury, Chantal; Henneman, Nathaniel F; Petrenko, Volodymyr; Shibayama, Yui; Segaloni, Arianna; Gadault, Alexis; Nemazanyy, Ivan; Le Guillou, Edouard; Wolide, Amare Desalegn; Antoniadou, Konstantina; Tong, Xin; Tamaru, Teruya; Ozawa, Takeaki; Girard, Muriel; Hnia, Karim; Lutter, Dominik; Dibner, Charna; Panasyuk, Ganna
Abstract:
Metabolic demands fluctuate rhythmically and rely on coordination between the circadian clock and nutrient-sensing signalling pathways, yet mechanisms of their interaction remain not fully understood. Surprisingly, we find that class 3 phosphatidylinositol-3-kinase (PI3K), known best for its essential role as a lipid kinase in endocytosis and lysosomal degradation by autophagy, has an overlooked nuclear function in gene transcription as a coactivator of the heterodimeric transcription factor and...     »
Journal title abbreviation:
Nat Cell Biol
Year:
2023
Journal volume:
25
Journal issue:
7
Pages contribution:
975-988
Fulltext / DOI:
doi:10.1038/s41556-023-01171-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37414850
Print-ISSN:
1465-7392
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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