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Titel:

High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Gruber, Tim; Lechner, Franziska; Murat, Cahuê; Contreras, Raian E; Sanchez-Quant, Eva; Miok, Viktorian; Makris, Konstantinos; Le Thuc, Ophélia; González-García, Ismael; García-Clave, Elena; Althammer, Ferdinand; Krabichler, Quirin; DeCamp, Lisa M; Jones, Russell G; Lutter, Dominik; Williams, Rhiannan H; Pfluger, Paul T; Müller, Timo D; Woods, Stephen C; Pospisilik, John Andrew; Martinez-Jimenez, Celia P; Tschöp, Matthias H; Grinevich, Valery; García-Cáceres, Cristina
Abstract:
Oxytocin-expressing paraventricular hypothalamic neurons (PVNOT neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, the molecular underpinnings by which PVNOT neurons orchestrate gut-to-brain feeding control remain unclear. Here, we show that mice undergoing selective ablation of PVNOT neurons fail to reduce food intake in response to CCK and develop hyperphagic obesity on a chow diet. Notably, exposing wild-type mi...     »
Zeitschriftentitel:
Cell Rep
Jahr:
2023
Band / Volume:
42
Heft / Issue:
10
Volltext / DOI:
doi:10.1016/j.celrep.2023.113305
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37864798
Print-ISSN:
2211-1247
TUM Einrichtung:
602; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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