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Titel:

Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis.

Dokumenttyp:
Journal Article
Autor(en):
Alkhoury, Chantal; Henneman, Nathaniel F; Petrenko, Volodymyr; Shibayama, Yui; Segaloni, Arianna; Gadault, Alexis; Nemazanyy, Ivan; Le Guillou, Edouard; Wolide, Amare Desalegn; Antoniadou, Konstantina; Tong, Xin; Tamaru, Teruya; Ozawa, Takeaki; Girard, Muriel; Hnia, Karim; Lutter, Dominik; Dibner, Charna; Panasyuk, Ganna
Abstract:
Metabolic demands fluctuate rhythmically and rely on coordination between the circadian clock and nutrient-sensing signalling pathways, yet mechanisms of their interaction remain not fully understood. Surprisingly, we find that class 3 phosphatidylinositol-3-kinase (PI3K), known best for its essential role as a lipid kinase in endocytosis and lysosomal degradation by autophagy, has an overlooked nuclear function in gene transcription as a coactivator of the heterodimeric transcription factor and...     »
Zeitschriftentitel:
Nat Cell Biol
Jahr:
2023
Band / Volume:
25
Heft / Issue:
7
Seitenangaben Beitrag:
975-988
Volltext / DOI:
doi:10.1038/s41556-023-01171-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37414850
Print-ISSN:
1465-7392
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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