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Titel:

TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.

Dokumenttyp:
Journal Article
Autor(en):
Khajavi, Noushafarin; Beck, Andreas; Ricku, Klea; Beyerle, Philipp; Jacob, Katharina; Syamsul, Sabrina F; Belkacemi, Anouar; Reinach, Peter S; Schreier, Pascale Cf; Salah, Houssein; Popp, Tanja; Novikoff, Aaron; Breit, Andreas; Chubanov, Vladimir; Müller, Timo D; Zierler, Susanna; Gudermann, Thomas
Abstract:
Most overweight individuals do not develop diabetes due to compensatory islet responses to restore glucose homeostasis. Therefore, regulatory pathways that promote β cell compensation are potential targets for treatment of diabetes. The transient receptor potential cation channel subfamily M member 7 protein (TRPM7), harboring a cation channel and a serine/threonine kinase, has been implicated in controlling cell growth and proliferation. Here, we report that selective deletion of Trpm7 in β cel...     »
Zeitschriftentitel:
JCI Insight
Jahr:
2023
Band / Volume:
8
Heft / Issue:
3
Volltext / DOI:
doi:10.1172/jci.insight.163397
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36574297
Print-ISSN:
2379-3708
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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