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Titel:

A Low Membrane Hsp70 Expression in Tumor Cells With Impaired Lactate Metabolism Mediates Radiosensitization by NVP-AUY922.

Dokumenttyp:
Journal Article
Autor(en):
Schwab, Melissa; Multhoff, Gabriele
Abstract:
As overexpression and membrane localization of stress proteins together with high lactate levels promote radioresistance in tumor cells, we studied the effect of the Hsp90 inhibitor NVP-AUY922 on the cytosolic and membrane expression of heat shock proteins (HSPs) and radiosensitivity in murine melanoma (B16F10) and human colorectal (LS174T) wildtype (WT) and lactate dehydrogenases A/B double knockout (LDH-/-) tumor cells. Double knockout for LDHA/B has been found to reduce cytosolic as well as m...     »
Zeitschriftentitel:
Front Oncol
Jahr:
2022
Band / Volume:
12
Volltext / DOI:
doi:10.3389/fonc.2022.861266
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35463341
Print-ISSN:
2234-943X
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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