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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Tagaeva, Ruslana; Efimova, Svetlana; Ischenko, Alexander; Zhakhov, Alexander; Shevtsov, Maxim; Ostroumova, Olga
Titel:
A new look at Hsp70 activity in phosphatidylserine-enriched membranes: chaperone-induced quasi-interdigitated lipid phase.
Abstract:
70 kDa heat shock protein Hsp70 (also termed HSP70A1A) is the major stress-inducible member of the HSP70 chaperone family, which is present on the plasma membranes of various tumor cells, but not on the membranes of the corresponding normal cells. The exact mechanisms of Hsp70 anchoring in the membrane and its membrane-related functions are still under debate, since the protein does not contain consensus signal sequence responsible for translocation from the cytosol to the lipid bilayer. The pre...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2023
Band / Volume:
13
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41598-023-46131-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37932471
Print-ISSN:
2045-2322
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)
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