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Title:

Late Effects of Chronic Low Dose Rate Total Body Irradiation on the Heart Proteome of ApoE-/- Mice Resemble Premature Cardiac Ageing.

Document type:
Journal Article
Author(s):
Azimzadeh, Omid; Merl-Pham, Juliane; Subramanian, Vikram; Oleksenko, Kateryna; Krumm, Franziska; Mancuso, Mariateresa; Pasquali, Emanuela; Tanaka, Ignacia B; Tanaka, Satoshi; Atkinson, Michael J; Tapio, Soile; Moertl, Simone
Abstract:
Recent epidemiologic studies support an association between chronic low-dose radiation exposure and the development of cardiovascular disease (CVD). The molecular mechanisms underlying the adverse effect of chronic low dose exposure are not fully understood. To address this issue, we have investigated changes in the heart proteome of ApoE deficient (ApoE-/-) C57Bl/6 female mice chronically irradiated for 300 days at a very low dose rate (1 mGy/day) or at a low dose rate (20 mGy/day), resulting i...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2023
Journal volume:
15
Journal issue:
13
Fulltext / DOI:
doi:10.3390/cancers15133417
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37444528
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)
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