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Title:

Dosimetric quantities and cell survival for spatially fractionated radiation therapy

Document type:
Article
Author(s):
Ahmed, Mabroor; Bicher, Sandra; Stewart, Robert D.; Bartzsch, Stefan; Schmid, Thomas E.; Combs, Stephanie E.; Meyer, Juergen
Abstract:
Purpose: Spatially Fractionated Radiation Therapy (SFRT) is characterized by large differences in peak and valley doses. Preclinical and clinical studies suggest that differences in biological mechanisms lead to differential normal tissue and tumor response compared to uniform irradiation. We hypothesize that to evaluate clinical effectiveness and understand fundamental biological mechanisms, radiobiological rather than physical dose quantities should be utilized for comparisons. The aim of this...     »
Journal title abbreviation:
Front. Physics
Year:
2023
Journal volume:
10
Fulltext / DOI:
doi:10.3389/fphy.2022.1064860
Print-ISSN:
2296-424X
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)
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