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Title:

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kemter, Elisabeth; Müller, Andreas; Neukam, Martin; Ivanova, Anna; Klymiuk, Nikolai; Renner, Simone; Yang, Kaiyuan; Broichhagen, Johannes; Kurome, Mayuko; Zakhartchenko, Valeri; Kessler, Barbara; Knoch, Klaus-Peter; Bickle, Marc; Ludwig, Barbara; Johnsson, Kai; Lickert, Heiko; Kurth, Thomas; Wolf, Eckhard; Solimena, Michele
Abstract:
β cells produce, store, and secrete insulin upon elevated blood glucose levels. Insulin secretion is a highly regulated process. The probability for insulin secretory granules to undergo fusion with the plasma membrane or being degraded is correlated with their age. However, the molecular features and stimuli connected to this behavior have not yet been fully understood. Furthermore, our understanding of β cell function is mostly derived from studies of ex vivo isolated islets in rodent models....     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2021
Journal volume:
118
Journal issue:
37
Fulltext / DOI:
doi:10.1073/pnas.2107665118
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34508004
Print-ISSN:
0027-8424
TUM Institution:
1693
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