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Titel:

Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets.

Dokumenttyp:
Article; Journal Article
Autor(en):
Rodriguez-Piñeiro, Ana M; Jaudas, Florian; Klymiuk, Nikolai; Bähr, Andrea; Hansson, Gunnar C; Ermund, Anna
Abstract:
BACKGROUND: The respiratory tract is protected from inhaled particles and microbes by mucociliary clearance, mediated by the mucus and the cilia creating a flow to move the mucus cephalad. Submucosal glands secrete linear MUC5B mucin polymers and because they pass through the gland duct before reaching the airway surface, bundled strands of 1000-5000 parallel molecules exit the glands. In contrast, the surface goblet cells secrete both MUC5AC and MUC5B. METHODS: We used mass-spectrometry based p...     »
Zeitschriftentitel:
Respir Res
Jahr:
2023
Band / Volume:
24
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s12931-023-02381-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36927357
Print-ISSN:
1465-9921
TUM Einrichtung:
Professur für Kardiovaskuläre Translation in Großtiermodellen (Prof. Klymiuk)
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