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Titel:

Phenotypic features of genetically modified DMD-XKOXWT pigs.

Dokumenttyp:
Journal Article
Autor(en):
Okamoto, Kazutoshi; Matsunari, Hitomi; Nakano, Kazuaki; Umeyama, Kazuhiro; Hasegawa, Koki; Uchikura, Ayuko; Takayanagi, Shuko; Watanabe, Masahito; Ohgane, Jun; Stirm, Michael; Kurome, Mayuko; Klymiuk, Nikolai; Nagaya, Masaki; Wolf, Eckhard; Nagashima, Hiroshi
Abstract:
INTRODUCTION: Duchenne muscular dystrophy (DMD) is a hereditary neuromuscular disorder caused by mutation in the dystrophin gene (DMD) on the X chromosome. Female DMD carriers occasionally exhibit symptoms such as muscle weakness and heart failure. Here, we investigated the characteristics and representativeness of female DMD carrier (DMD-XKOXWT) pigs as a suitable disease model. METHODS: In vitro fertilization using sperm from a DMD-XKOY↔XWTXWT chimeric boar yielded DMD-XKOXWT females, which we...     »
Zeitschriftentitel:
Regen Ther
Jahr:
2023
Band / Volume:
24
Seitenangaben Beitrag:
451-458
Volltext / DOI:
doi:10.1016/j.reth.2023.09.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37772130
TUM Einrichtung:
Professur für Kardiovaskuläre Translation in Großtiermodellen (Prof. Klymiuk)
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