Benutzer: Gast  Login
Weniger Felder
Einfache Suche
Titel:

A scalable, clinically severe pig model for Duchenne muscular dystrophy.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Stirm, Michael; Fonteyne, Lina Marie; Shashikadze, Bachuki; Lindner, Magdalena; Chirivi, Maila; Lange, Andreas; Kaufhold, Clara; Mayer, Christian; Medugorac, Ivica; Kessler, Barbara; Kurome, Mayuko; Zakhartchenko, Valeri; Hinrichs, Arne; Kemter, Elisabeth; Krause, Sabine; Wanke, Rüdiger; Arnold, Georg J; Wess, Gerhard; Nagashima, Hiroshi; Hrabĕ de Angelis, Martin; Flenkenthaler, Florian; Kobelke, Levin Arne; Bearzi, Claudia; Rizzi, Roberto; Bähr, Andrea; Reese, Sven; Matiasek, Kaspar; Walter, Ma...     »
Abstract:
Large-animal models for Duchenne muscular dystrophy (DMD) are crucial for the evaluation of diagnostic procedures and treatment strategies. Pigs cloned from male cells lacking DMD exon 52 (DMDΔ52) exhibit molecular, clinical and pathological hallmarks of DMD, but die before sexual maturity and cannot be propagated by breeding. Therefore, we generated female DMD+/- carriers. A single founder animal had 11 litters with 29 DMDY/-, 34 DMD+/- as well as 36 male and 29 female wild-type offspring. Bree...     »
Zeitschriftentitel:
Dis Model Mech
Jahr:
2021
Band / Volume:
14
Heft / Issue:
12
Volltext / DOI:
doi:10.1242/dmm.049285
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34796900
Print-ISSN:
1754-8403
TUM Einrichtung:
1693; 617; Klinik und Poliklinik für Innere Medizin I, Kardiologie
 BibTeX