Longitudinal analysis of systemic ventricular function and atrioventricular valve function after the Fontan procedure.

Dahmen, Vincent; Heinisch, Paul Philipp; Staehler, Helena; Schaeffer, Thibault; Burri, Melchior; Röhlig, Christoph; Klawonn, Frank; Hager, Alfred; Ewert, Peter; Hörer, Jürgen; Ono, Masamichi

doi:10.1093/ejcts/ezad078

Klinik für Chirurgie angeborener Herzfehler und Kinderherzchirurgie (DHM) (Prof. Hörer)

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Titel:: Longitudinal analysis of systemic ventricular function and atrioventricular valve function after the Fontan procedure.
Dokumenttyp:: Journal Article
Autor(en):: Dahmen, Vincent; Heinisch, Paul Philipp; Staehler, Helena; Schaeffer, Thibault; Burri, Melchior; Röhlig, Christoph; Klawonn, Frank; Hager, Alfred; Ewert, Peter; Hörer, Jürgen; Ono, Masamichi
Abstract:: OBJECTIVES: This study aimed to determine the longitudinal change of systemic ventricular function and atrioventricular valve (AVV) regurgitation after total cavopulmonary connection (TCPC). METHODS: In 620 patients who underwent TCPC between 1994 and 2021, 4219 longitudinal echocardiographic examinations of systemic ventricular function and AVV regurgitation were evaluated retrospectively. RESULTS: The most frequent primary diagnosis was hypoplastic left heart syndrome in 172, followed by single ventricle in 131, tricuspid atresia in 95 and double inlet left ventricle (LV) in 91 patients. Dominant right ventricle (RV) was observed in 329 (53%) and dominant LV in 291 (47%). The median age at TCPC was 2.3 (1.8-3.4) years. Transplant-free survival at 5, 10 and 15 years after TCPC was 96.3%, 94.7% and 93.6%, respectively, in patients with dominant RV and 97.3%, 94.6% and 94.6%, respectively, in those with dominant LV (P = 0.987). Longitudinal analysis of systemic ventricular function was similar in both groups during the first 10 years postoperatively. Thereafter, systemic ventricular function worsened significantly in patients with dominant RV, compared with those with dominant LV (15 years: P = 0.007, 20 years: P = 0.03). AVV regurgitation was more frequent after TCPC in patients with dominant RV compared with those with dominant LV (P < 0.001 at 3 months, 3 years, 5 years, 10 years and 15 years, P = 0.023 at 20 years). There was a significant correlation between postoperative systemic ventricular dysfunction and AVV regurgitation (P < 0.001). CONCLUSIONS: There were no transplant-free survival difference and no difference in ventricular function between dominant RV and dominant LV for the first 10 years after TCPC. Thereafter, ventricular function in dominant RV was inferior to that in dominant LV. The degree of AVV regurgitation was significantly higher in dominant RV, compared with dominant LV, and it was positively associated with ventricular dysfunction, especially in dominant RV.
Zeitschriftentitel:: Eur J Cardiothorac Surg
Jahr:: 2023
Band / Volume:: 63
Heft / Issue:: 6
Volltext / DOI:: doi:10.1093/ejcts/ezad078
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/36857588
Print-ISSN:: 1010-7940
TUM Einrichtung:: Klinik für Chirurgie angeborener Herzfehler und Kinderherzchirurgie (DHM) (Prof. Hörer); Klinik für Herz- und Gefäßchirurgie (DHM) (Prof. Krane); Klinik und Poliklinik für Urologie (Prof. Gschwend)
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