Correlation of Myocardial Native T1 and Left Ventricular Reverse Remodeling after Valvular Surgery.

von Stumm, Maria; Petersen, Johannes; Sinn, Martin; Holst, Theresa; Sequeira-Gross, Tatiana M; Müller, Lisa; Pausch, Jonas; Bannas, Peter; Adam, Gerhard; Reichenspurner, Hermann; Girdauskas, Evaldas

doi:10.3390/jcm12072649

Klinik für Chirurgie angeborener Herzfehler und Kinderherzchirurgie (DHM) (Prof. Hörer)

Back
Back to start of result list
Permanent link for displayed object

Document type:: Journal Article
Author(s):: von Stumm, Maria; Petersen, Johannes; Sinn, Martin; Holst, Theresa; Sequeira-Gross, Tatiana M; Müller, Lisa; Pausch, Jonas; Bannas, Peter; Adam, Gerhard; Reichenspurner, Hermann; Girdauskas, Evaldas
Title:: Correlation of Myocardial Native T1 and Left Ventricular Reverse Remodeling after Valvular Surgery.
Abstract:: Myocardial native T1 is a known cardiovascular magnetic resonance (CMR) imaging biomarker to quantify diffuse myocardial fibrosis in valvular cardiomyopathy. We hypothesized that diffuse myocardial fibrosis assessed by preoperative T1 mapping might correlate with LV reverse remodeling after valvular surgery. A prospective monocentric cohort study was conducted including 79 consecutive patients with valvular cardiomyopathy referred for surgical treatment of severe aortic or severe functional mitral regurgitation. Native T1 values were assessed by CMR before surgery. LV geometry parameters (i.e., LVEDV, LVESV) were obtained by 2D transthoracic echocardiography before and six months after surgery. Postoperative change of LV geometry parameters was calculated as delta (∆) variable (i.e., six months value minus baseline value). Mean native T1 was 1047 ± 39 ms, mean ∆LVEDV was -33 ± 42 mL, and mean ∆LVESV was -15 ± 27 mL. Native T1 values correlated with ∆LVEDV (Pearson r = 0.29; p = 0.009) and ∆LVESV (Pearson r = 0.29; p = 0.015). Native T1 values < 1073 ms were identified as independent predictor of postoperative reduction of LVEDV (HR 3.0; 95%-CI: 1.1-8.0; p = 0.03) and LVESV (HR 2.9; 95%-CI: 1.1-7.4; p = 0.03). Diffuse myocardial fibrosis assessed by myocardial native T1 correlates with LV reverse remodeling at six months after valvular surgery. T1 mapping may be a valuable tool to predict LV reverse remodeling in valvular heart disease.
Journal title abbreviation:: J Clin Med
Year:: 2023
Journal volume:: 12
Journal issue:: 7
Fulltext / DOI:: doi:10.3390/jcm12072649
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/37048732
TUM Institution:: Klinik für Chirurgie angeborener Herzfehler und Kinderherzchirurgie (DHM) (Prof. Hörer)
BibTeX

Occurrences:

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Chirurgie angeborener Herzfehler und Kinderherzchirurgie (DHM) (Prof. Hörer)2023