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Title:

Voxel-based morphometry indicates relative preservation of the limbic prefrontal cortex in early Huntington disease.

Document type:
Journal Article; Article
Author(s):
Muhlau, M; Weindl, A; Wohlschläger, AM; Gaser, C; Städtler, M; Valet, M; Zimmer, C; Kassubek, J; Peinemann, A
Abstract:
In Huntington disease (HD), both the genetic defect and mutant gene product huntington are known but the exact mechanisms that lead to neuronal loss are poorly understood. Until now, the distribution of tissue loss throughout the brain has been investigated intensively. Here we searched for areas that, antipodal to the striatum, display grey-matter (GM) preservation. We performed high resolution T1-weighted magnetic resonance imaging and voxel-based morphometry in 46 patients in early HD and 46...     »
Journal title abbreviation:
J Neural Transm
Year:
2007
Journal volume:
114
Journal issue:
3
Pages contribution:
367-72
Language:
eng
Fulltext / DOI:
doi:10.1007/s00702-006-0571-x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17024326
Print-ISSN:
0300-9564
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer); Neurologische Klinik und Poliklinik
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