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Title:

Wound infiltrating adipocytes are not myofibroblasts.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kalgudde Gopal, Shruthi; Dai, Ruoxuan; Stefanska, Ania Maria; Ansari, Meshal; Zhao, Jiakuan; Ramesh, Pushkar; Bagnoli, Johannes W; Correa-Gallegos, Donovan; Lin, Yue; Christ, Simon; Angelidis, Ilias; Lupperger, Valerio; Marr, Carsten; Davies, Lindsay C; Enard, Wolfgang; Machens, Hans-Günther; Schiller, Herbert B; Jiang, Dongsheng; Rinkevich, Yuval
Abstract:
The origins of wound myofibroblasts and scar tissue remains unclear, but it is assumed to involve conversion of adipocytes into myofibroblasts. Here, we directly explore the potential plasticity of adipocytes and fibroblasts after skin injury. Using genetic lineage tracing and live imaging in explants and in wounded animals, we observe that injury induces a transient migratory state in adipocytes with vastly distinct cell migration patterns and behaviours from fibroblasts. Furthermore, migratory...     »
Journal title abbreviation:
Nat Commun
Year:
2023
Journal volume:
14
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-023-38591-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37230982
Print-ISSN:
2041-1723
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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