Quality of life in patients with Fabry's disease: a cross-sectional study of 86 adults.

Andonian, Caroline; Beckmann, Jürgen; Mayer, Oliver; Ewert, Peter; Freiberger, Annika; Huber, Maximilian; Kaemmerer, Harald; Kurschat, Christine; Lagler, Florian; Nagdyman, Nicole; Pieper, Lars; Regenbogen, Claudia; Freilinger, Sebastian

doi:10.21037/cdt-22-215

journal article

Title:: Quality of life in patients with Fabry's disease: a cross-sectional study of 86 adults.
Document type:: Journal Article
Author(s):: Andonian, Caroline; Beckmann, Jürgen; Mayer, Oliver; Ewert, Peter; Freiberger, Annika; Huber, Maximilian; Kaemmerer, Harald; Kurschat, Christine; Lagler, Florian; Nagdyman, Nicole; Pieper, Lars; Regenbogen, Claudia; Freilinger, Sebastian
Abstract:: BACKGROUND: Fabry disease (FD) is a multi-organ disorder associated with severe physical and psychological impairments, particularly in adulthood. To date, comprehensive data on the psychological burden of FD are lacking. The present study assessed quality of life (QOL) in a representative cohort of adults with FD. METHODS: Patient-reported outcome measures were retrospectively analyzed in 86 adults with FD (49.6±16.6 years; 62.8% female) and compared to adults with congenital heart defects (ACHD) which is another lifelong disease and affliction. QOL was assessed using the European Quality of Life 5 Dimensions 5 Levels questionnaire (EQ-5D-5L). RESULTS: Subjects affected by FD reported an overall reduced QOL (EQ-VAS: 71.8±20.0). Most frequently reported complaints occurred within the dimensions pain/discomfort (69.7%), daily activities (48.9%) and anxiety/depression (45.4%). Compared to ACHD, individuals with FD scored significantly lower in the areas of pain/discomfort, usual activities and mobility (all P<0.05). Older age and female sex were particularly associated with diminished QOL (P=0.05). CONCLUSIONS: Patients with FD are at high risk for impaired QOL. They require additional support to cope with disease-related challenges. Increased attention should be directed towards improving their subjective well-being to potentially increase their QOL and long-term health outcomes.
Journal title abbreviation:: Cardiovasc Diagn Ther
Year:: 2022
Journal volume:: 12
Journal issue:: 4
Pages contribution:: 426-435
Fulltext / DOI:: doi:10.21037/cdt-22-215
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/36033224
Print-ISSN:: 2223-3652
TUM Institution:: Klinik für Kinderkardiologie und angeborene Herzfehler (DHM) (Prof. Ewert); Professur für Nephrologie (Prof. Heemann)
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Occurrences:

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)Abteilung für Nephrologie (Prof. Heemann)Professur für Nephrologie (Prof. Heemann)2022

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Kinderkardiologie und angeborene Herzfehler (DHM) (Prof. Ewert)2022