User: Guest  Login
Title:

A Simple Classification of Pancreatic Duct Size and Texture Predicts Postoperative Pancreatic Fistula: A classification of the International Study Group of Pancreatic Surgery.

Document type:
Meta-Analysis; Journal Article
Author(s):
Schuh, Fabian; Mihaljevic, André L; Probst, Pascal; Trudeau, Maxwell T; Müller, Philip C; Marchegiani, Giovanni; Besselink, Marc G; Uzunoglu, Faik; Izbicki, Jakob R; Falconi, Massimo; Fernandez-Del Castillo, Carlos; Adham, Mustapha; Z'graggen, Kaspar; Friess, Helmut; Werner, Jens; Weitz, Jürgen; Strobel, Oliver; Hackert, Thilo; Radenkovic, Dejan; Kelemen, Dezső; Wolfgang, Christopher; Miao, Y I; Shrikhande, Shailesh V; Lillemoe, Keith D; Dervenis, Christos; Bassi, Claudio; Neoptolemos, John P; D...     »
Abstract:
OBJECTIVE: The aim of this study was to develop a classification system for pancreas-associated risk factors in pancreatoduodenectomy (PD). SUMMARY BACKGROUND DATA: Postoperative pancreatic fistula (POPF) is the most relevant PD-associated complication. A simple standardized surgical reporting system based on pancreas-associated risk factors is lacking. METHODS: A systematic literature search was conducted to identify studies investigating clinically relevant (CR) POPF (CR-POPF) and pancreas-associated risk factors after PD. A meta-analysis of CR-POPF rate for texture of the pancreas (soft vs not-soft) and main pancreatic duct (MPD) diameter was performed using the Mantel-Haenszel method. Based on the results, the International Study Group of Pancreatic Surgery (ISGPS) proposes the following classification: A, not-soft (hard) texture and MPD >3 mm; B, not-soft (hard) texture and MPD ≤3 mm; C, soft texture and MPD >3 mm; D, soft texture and MPD ≤3 mm. The classification was evaluated in a multi-institutional, international cohort. RESULTS: Of the 2917 articles identified, 108 studies were included in the analyses. Soft pancreatic texture was significantly associated with the development of CR-POPF [odds ratio (OR) 4.24, 95% confidence interval (CI) 3.67-4.89, P < 0.01) following PD. Similarly, MPD diameter ≤3 mm significantly increased CR-POPF risk compared with >3 mm diameter MPDs (OR 3.66, 95% CI 2.62-5.12, P < 0.01). The proposed 4-stage system was confirmed in an independent cohort of 5533 patients with CR-POPF rates of 3.5%, 6.2%, 16.6%, and 23.2% for type A-D, respectively ( P < 0.001). CONCLUSION: For future pancreatic surgical outcomes studies, the ISGPS recommends reporting these risk factors according to the proposed classification system for better comparability of results.
Journal title abbreviation:
Ann Surg
Year:
2023
Journal volume:
277
Journal issue:
3
Pages contribution:
e597-e608
Fulltext / DOI:
doi:10.1097/SLA.0000000000004855
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33914473
Print-ISSN:
0003-4932
TUM Institution:
591; Klinik und Poliklinik für Chirurgie (Prof. Friess)
 BibTeX