Treatment characteristics and outcomes of pure Acinar cell carcinoma of the pancreas - A multicentric European study on radically resected patients.

Bellotti, Ruben; Paiella, Salvatore; Primavesi, Florian; Jäger, Carsten; Demir, Ihsan E; Casciani, Fabio; Kornprat, Peter; Wagner, Doris; Rösch, Christiane S; Butturini, Giovanni; Giardino, Alessandro; Goretzky, Peter E; Mogl, Martina; Fahlbusch, Tim; Kaiser, Jörg; Strobel, Oliver; Nießen, Anna; Luu, Andreas M; Salvia, Roberto; Maglione, Manuel

doi:10.1016/j.hpb.2023.07.897

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Title:: Treatment characteristics and outcomes of pure Acinar cell carcinoma of the pancreas - A multicentric European study on radically resected patients.
Document type:: Article; Journal Article
Author(s):: Bellotti, Ruben; Paiella, Salvatore; Primavesi, Florian; Jäger, Carsten; Demir, Ihsan E; Casciani, Fabio; Kornprat, Peter; Wagner, Doris; Rösch, Christiane S; Butturini, Giovanni; Giardino, Alessandro; Goretzky, Peter E; Mogl, Martina; Fahlbusch, Tim; Kaiser, Jörg; Strobel, Oliver; Nießen, Anna; Luu, Andreas M; Salvia, Roberto; Maglione, Manuel
Abstract:: BACKGROUND: Acinar cell carcinomas (ACC) belong to the exocrine pancreatic malignancies. Due to their rarity, there is no consensus regarding treatment strategies for resectable ACC. METHODS: This is a retrospective multicentric study of radically resected pure pancreatic ACC. Primary endpoints were overall survival (OS) and disease-free survival (DFS). Further endpoints were oncologic outcomes related to tumor stage and therapeutic protocols. RESULTS: 59 patients (44 men) with a median age of 64 years were included. The median tumor size was 45.0 mm. 61.0% were pT3 (n = 36), nodal positivity rate was 37.3% (n = 22), and synchronous distant metastases were present in 10.1% of the patients (n = 6). 5-Years OS was 60.9% and median DFS 30 months. 24 out of 31 recurred systemically (n = 18 only systemic, n = 6 local and systemic). Regarding TNM-staging, only the N2-stage negatively influenced OS and DFS (p = 0.004, p = 0.001). Adjuvant treatment protocols (performed in 62.7%) did neither improve OS (p = 0.542) nor DFS (p = 0.159). In 9 cases, radical resection was achieved following neoadjuvant therapy. DISCUSSION: Radical surgery is currently the mainstay for resectable ACC, even for limited metastatic disease. Novel (neo)adjuvant treatment strategies are needed, since current systemic therapies do not result in a clear survival benefit in the perioperative setting. «
BACKGROUND: Acinar cell carcinomas (ACC) belong to the exocrine pancreatic malignancies. Due to their rarity, there is no consensus regarding treatment strategies for resectable ACC. METHODS: This is a retrospective multicentric study of radically resected pure pancreatic ACC. Primary endpoints were overall survival (OS) and disease-free survival (DFS). Further endpoints were oncologic outcomes related to tumor stage and therapeutic protocols. RESULTS: 59 patients (44 men) with a median age of 6... »
Journal title abbreviation:: HPB (Oxford)
Year:: 2023
Journal volume:: 25
Journal issue:: 11
Pages contribution:: 1411-1419
Fulltext / DOI:: doi:10.1016/j.hpb.2023.07.897
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/37563033
Print-ISSN:: 1365-182X
TUM Institution:: 1200; Klinik und Poliklinik für Chirurgie (Prof. Friess)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Chirurgie (Prof. Friess)2023