Cardiogenesis is a highly dynamic process relying on the precise spatiotemporal coordination of progenitor cell populations. Understanding the specification of these progenitors during early human development is crucial for advancing our knowledge of congenital cardiac malformations. Here, we used a combination of genetic labeling, cell sorting, and bulk and single-cell transcriptional profiling to thoroughly characterize various mesodermal progenitor pools and their definitive progenies emerging during cardiac differentiation of human pluripotent stem cells.
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Cardiogenesis is a highly dynamic process relying on the precise spatiotemporal coordination of progenitor cell populations. Understanding the specification of these progenitors during early human development is crucial for advancing our knowledge of congenital cardiac malformations. Here, we used a combination of genetic labeling, cell sorting, and bulk and single-cell transcriptional profiling to thoroughly characterize various mesodermal progenitor pools and their definitive progenies emergin...
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