NCALD as a potential predictive biomarker for the efficacy of platinum-based chemotherapy in ovarian cancer.

Konrad, Sarah M; Schwamborn, Kristina; Krüger, Achim; Honert, Katja; Schmitt, Manfred; Hellmann, Daniela; Schmalfeldt, Barbara; Meindl, Alfons; Kiechle, Marion; Quante, Anne S; Brambs, Christine; Grill, Sabine; Ramser, Juliane

doi:10.2217/bmm-2021-0781

2022

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Title:: NCALD as a potential predictive biomarker for the efficacy of platinum-based chemotherapy in ovarian cancer.
Document type:: Journal Article
Author(s):: Konrad, Sarah M; Schwamborn, Kristina; Krüger, Achim; Honert, Katja; Schmitt, Manfred; Hellmann, Daniela; Schmalfeldt, Barbara; Meindl, Alfons; Kiechle, Marion; Quante, Anne S; Brambs, Christine; Grill, Sabine; Ramser, Juliane
Abstract:: Aim: Since reliable response predictors to platinum-based chemotherapy in ovarian cancer (OC) are scarce, we characterize NCALD as a predictive biomarker. Materials & methods: NCALD mRNA (n = 100) and protein (n = 102) expression was analyzed in OC samples and associated with patient outcome. A stable OC cell line knockdown was generated and cellular response to platinum was explored. Results: High NCALD mRNA and protein expression was significantly associated with longer overall patient survival (p = 0.037/0.002). Knockdown experiments revealed a significant association between cisplatin sensitivity and NCALD expression. Conclusion: Low NCALD expression was associated with reduced sensitivity to platinum-based chemotherapy. NCALD may be a new biomarker candidate to identify patients who might benefit from platinum-based chemotherapy.
Journal title abbreviation:: Biomark Med
Year:: 2022
Journal volume:: 16
Journal issue:: 14
Pages contribution:: 1029-1041
Fulltext / DOI:: doi:10.2217/bmm-2021-0781
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/36444691
Print-ISSN:: 1752-0363
TUM Institution:: 597; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Frauenheilkunde
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mediaTUM Gesamtbestand Hochschulbibliographie 2022 Schools und Fakultäten Medizin Institut für Allgemeine Pathologie und Pathologische Anatomie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Ehemalige Einrichtungen Institut für Experimentelle Onkologie und Therapieforschung 2022

mediaTUM Gesamtbestand Hochschulbibliographie 2022 Schools und Fakultäten Medizin Institut für Experimentelle Onkologie und Therapieforschung

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Frauenheilkunde (Prof. Kiechle)2022

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Preclinical Medicine Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)2022