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Title:

NCALD as a potential predictive biomarker for the efficacy of platinum-based chemotherapy in ovarian cancer.

Document type:
Journal Article
Author(s):
Konrad, Sarah M; Schwamborn, Kristina; Krüger, Achim; Honert, Katja; Schmitt, Manfred; Hellmann, Daniela; Schmalfeldt, Barbara; Meindl, Alfons; Kiechle, Marion; Quante, Anne S; Brambs, Christine; Grill, Sabine; Ramser, Juliane
Abstract:
Aim: Since reliable response predictors to platinum-based chemotherapy in ovarian cancer (OC) are scarce, we characterize NCALD as a predictive biomarker. Materials & methods: NCALD mRNA (n = 100) and protein (n = 102) expression was analyzed in OC samples and associated with patient outcome. A stable OC cell line knockdown was generated and cellular response to platinum was explored. Results: High NCALD mRNA and protein expression was significantly associated with longer overall patient survival (p = 0.037/0.002). Knockdown experiments revealed a significant association between cisplatin sensitivity and NCALD expression. Conclusion: Low NCALD expression was associated with reduced sensitivity to platinum-based chemotherapy. NCALD may be a new biomarker candidate to identify patients who might benefit from platinum-based chemotherapy.
Journal title abbreviation:
Biomark Med
Year:
2022
Journal volume:
16
Journal issue:
14
Pages contribution:
1029-1041
Fulltext / DOI:
doi:10.2217/bmm-2021-0781
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36444691
Print-ISSN:
1752-0363
TUM Institution:
597; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Frauenheilkunde
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