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Title:

Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Koerber, Nina; Priller, Alina; Yazici, Sarah; Bauer, Tanja; Cheng, Cho-Chin; Mijočević, Hrvoje; Wintersteller, Hannah; Jeske, Samuel; Vogel, Emanuel; Feuerherd, Martin; Tinnefeld, Kathrin; Winter, Christof; Ruland, Jürgen; Gerhard, Markus; Haller, Bernhard; Christa, Catharina; Zelger, Otto; Roggendorf, Hedwig; Halle, Martin; Erber, Johanna; Lingor, Paul; Keppler, Oliver; Zehn, Dietmar; Protzer, Ulrike; Knolle, Percy A
Abstract:
Anti-viral immunity continuously declines over time after SARS-CoV-2 infection. Here, we characterize the dynamics of anti-viral immunity during long-term follow-up and after BNT162b2 mRNA-vaccination in convalescents after asymptomatic or mild SARS-CoV-2 infection. Virus-specific and virus-neutralizing antibody titers rapidly declined in convalescents over 9 months after infection, whereas virus-specific cytokine-producing polyfunctional T cells persisted, among which IL-2-producing T cells cor...     »
Journal title abbreviation:
Nat Commun
Year:
2022
Journal volume:
13
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-021-27649-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35013191
Print-ISSN:
2041-1723
TUM Institution:
Institut für KI und Informatik in der Medizin (Prof. Rückert); Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch); Institut für Virologie (Prof. Protzer); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid); Klinik und Poliklinik für Neurologie (Prof. Hemmer); Lehrstuhl für Medizinische Informatik (Prof. Boeker); Poliklinik für Präventive Sportmedizin und Sportkardiologie (Prof....     »
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