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Title:

Identification of invariant chain CD74 as a functional receptor of tissue inhibitor of metalloproteinases-1 (TIMP-1).

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Schoeps, Benjamin; Eckfeld, Celina; Flüter, Laura; Keppler, Selina; Mishra, Ritu; Knolle, Percy; Bayerl, Felix; Böttcher, Jan; Hermann, Chris D; Häußler, Daniel; Krüger, Achim
Abstract:
Multifunctionality of tissue inhibitor of metalloproteinases-1 (TIMP-1) comprising antiproteolytic as well as cytokinic activity has been attributed to its N-terminal and C-terminal domains, respectively. The molecular basis of the emerging proinflammatory cytokinic activity of TIMP-1 is still not completely understood. The cytokine receptor invariant chain (CD74) is involved in many inflammation-associated diseases and is highly expressed by immune cells. CD74 triggers zeta chain-associated pro...     »
Journal title abbreviation:
J Biol Chem
Year:
2021
Journal volume:
297
Journal issue:
3
Fulltext / DOI:
doi:10.1016/j.jbc.2021.101072
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34391782
Print-ISSN:
0021-9258
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Institut für Klinische Chemie und Pathobiochemie; Roman Herzog Comprehensive Cancer Center
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