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Title:

Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Morigny, Pauline; Kaltenecker, Doris; Zuber, Julia; Machado, Juliano; Mehr, Lisa; Tsokanos, Foivos-Filippos; Kuzi, Hanna; Hermann, Chris D; Voelkl, Michael; Monogarov, German; Springfeld, Christoph; Laurent, Victor; Engelmann, Bernd; Friess, Helmut; Zörnig, Inka; Krüger, Achim; Krijgsveld, Jeroen; Prokopchuk, Olga; Fisker Schmidt, Søren; Rohm, Maria; Herzig, Stephan; Berriel Diaz, Mauricio
Abstract:
BACKGROUND: Cancer cachexia (CCx) is a multifactorial wasting disorder characterized by involuntary loss of body weight that affects many cancer patients and implies a poor prognosis, reducing both tolerance to and efficiency of anticancer therapies. Actual challenges in management of CCx remain in the identification of tumour-derived and host-derived mediators involved in systemic inflammation and tissue wasting and in the discovery of biomarkers that would allow for an earlier and personalized...     »
Journal title abbreviation:
J Cachexia Sarcopenia Muscle
Year:
2021
Journal volume:
12
Journal issue:
5
Pages contribution:
1333-1351
Fulltext / DOI:
doi:10.1002/jcsm.12758
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34427055
Print-ISSN:
2190-5991
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Chirurgie
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