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Titel:

TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer.

Dokumenttyp:
Journal Article
Autor(en):
Schoeps, Benjamin; Eckfeld, Celina; Prokopchuk, Olga; Böttcher, Jan; Häußler, Daniel; Steiger, Katja; Demir, Ihsan Ekin; Knolle, Percy; Soehnlein, Oliver; Jenne, Dieter E; Hermann, Chris D; Krüger, Achim
Abstract:
Tumor-derived protein tissue inhibitor of metalloproteinases-1 (TIMP1) correlates with poor prognosis in many cancers, including highly lethal pancreatic ductal adenocarcinoma (PDAC). The noncanonical signaling activity of TIMP1 is emerging as one basis for its contribution to cancer progression. However, TIMP1-triggered progression-related biological processes are largely unknown. Formation of neutrophil extracellular traps (NET) in the tumor microenvironment is known to drive progression of PD...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2021
Band / Volume:
81
Heft / Issue:
13
Seitenangaben Beitrag:
3568-3579
Volltext / DOI:
doi:10.1158/0008-5472.CAN-20-4125
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33941611
Print-ISSN:
0008-5472
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Chirurgie; Roman Herzog Comprehensive Cancer Center
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