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- Document type:
- Journal Article
- Author(s):
- Wranicz, Jerzy Krzysztof; Kałowski, Michał; Bastian, Dirk; Jaswal, Aparna; Kolb, Christof; Zitron, Edgar; Cygankiewicz, Iwona; Kaczmarek, Krzysztof
- Title:
- Clinical valuation of ST changes in a group of patients with ventricular arrhythmias: The inSighT Study.
- Abstract:
- BACKGROUND: The inSighT study was designed to determine the prevalence of ischemic changes as recorded by implantable cardioverter-defibrillator (ICD) ST deviations in intracardiac electrocardiograms (EGM) over the 24 h preceding malignant ventricular arrhythmias (VT/VF). METHODS: The study enrolled patients with known coronary artery disease (CAD) or high risk of future development of CAD implanted with an ICD equipped with an ST monitoring feature (Ellipse™/Fortify Assura™, St. Jude Medical). Device session records were collected at each in-clinic follow-up. EGM ST levels of the beats over the 15 minutes prior to VT/VF events were compared using a t test with those from a baseline period of 23-24 h prior to the VT/VF event. All events with p < .05 were visually inspected to confirm they were evaluable; additional criteria for exclusion from further analysis included inappropriate therapy, aberrant conduction, and occurrence of VT/VF within 24h prior to the current event. RESULTS: The study enrolled 481 ICD patients (64 ± 11 years, 83% male) in 14 countries and followed them for 15±5 months. A total of 165 confirmed VT/VF episodes were observed, of which 71 events (in 56 patients, 34% of all patients with VT/VF) were preceded by significant (p < .05) ST-segment changes unrelated to known non-ischemic causes. None of the analyzed demographic and clinical factors proved to be associated with greater odds of presenting with ST-segment changes prior to VT/VF episode. CONCLUSION: In this exploratory study, characteristic ST-segment changes, likely representative of ischemic events, were observed in 34% of all patients with VT/VF episodes.
- Journal title abbreviation:
- Ann Noninvasive Electrocardiol
- Year:
- 2022
- Journal volume:
- 27
- Journal issue:
- 3
- Fulltext / DOI:
- doi:10.1111/anec.12914
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/35170151
- Print-ISSN:
- 1082-720X
- TUM Institution:
- Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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