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Titel:

PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the "Cancer Integrin" αvβ6 with Ga-68-Trivehexin.

Dokumenttyp:
Journal Article
Autor(en):
Quigley, Neil Gerard; Steiger, Katja; Hoberück, Sebastian; Czech, Norbert; Zierke, Maximilian Alexander; Kossatz, Susanne; Pretze, Marc; Richter, Frauke; Weichert, Wilko; Pox, Christian; Kotzerke, Jörg; Notni, Johannes
Abstract:
PURPOSE: To develop a new probe for the αvβ6-integrin and assess its potential for PET imaging of carcinomas. METHODS: Ga-68-Trivehexin was synthesized by trimerization of the optimized αvβ6-integrin selective cyclic nonapeptide Tyr2 (sequence: c[YRGDLAYp(NMe)K]) on the TRAP chelator core, followed by automated labeling with Ga-68. The tracer was characterized by ELISA for activities towards integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1, as well as by cell binding assays on H2009 (αvβ6-positive)...     »
Zeitschriftentitel:
Eur J Nucl Med Mol Imaging
Jahr:
2022
Band / Volume:
49
Heft / Issue:
4
Seitenangaben Beitrag:
1136-1147
Volltext / DOI:
doi:10.1007/s00259-021-05559-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34559266
Print-ISSN:
1619-7070
TUM Einrichtung:
1413; Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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