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Title:

Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.

Document type:
Letter; Letter; Research Support, Non-U.S. Gov't
Author(s):
Poeck, Hendrik; Wintges, Alexander; Dahl, Sarah; Bassermann, Florian; Haas, Tobias; Heidegger, Simon
Abstract:
Immunogenic cancer therapies, including radiation and hypomethylating agents, such as 5-azacytidine, rely on tumor cell-intrinsic activation of the RNA receptor RIG-I for their synergism with immune checkpoint inhibitors. Possible RIG-I ligands are small nuclear RNA (snRNA) and endogenous retroviral elements (ERV) leaking from the nucleus during programmed cell death.
Journal title abbreviation:
Eur J Immunol
Year:
2021
Journal volume:
51
Journal issue:
6
Pages contribution:
1531-1534
Fulltext / DOI:
doi:10.1002/eji.202049158
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33733474
Print-ISSN:
0014-2980
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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