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Title:

Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lutomska, Luiza Maria; Miok, Viktorian; Krahmer, Natalie; González García, Ismael; Gruber, Tim; Le Thuc, Ophélia; Murat, Cahuê Db; Legutko, Beata; Sterr, Michael; Saher, Gesine; Lickert, Heiko; Müller, Timo D; Ussar, Siegfried; Tschöp, Matthias H; Lutter, Dominik; García-Cáceres, Cristina
Abstract:
Hypothalamic astrocytes are particularly affected by energy-dense food consumption. How the anatomical location of these glial cells and their spatial molecular distribution in the arcuate nucleus of the hypothalamus (ARC) determine the cellular response to a high caloric diet remains unclear. In this study, we investigated their distinctive molecular responses following exposure to a high-fat high-sugar (HFHS) diet, specifically in the ARC. Using RNA sequencing and proteomics, we showed that as...     »
Journal title abbreviation:
Glia
Year:
2022
Journal volume:
70
Journal issue:
11
Pages contribution:
2062-2078
Fulltext / DOI:
doi:10.1002/glia.24237
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35802021
Print-ISSN:
0894-1491
TUM Institution:
602; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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