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Title:

Insulin regulates neurovascular coupling through astrocytes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Fernandez, Ana M; Martinez-Rachadell, Laura; Navarrete, Marta; Pose-Utrilla, Julia; Davila, Jose Carlos; Pignatelli, Jaime; Diaz-Pacheco, Sonia; Guerra-Cantera, Santiago; Viedma-Moreno, Emilia; Palenzuela, Rocio; Ruiz de Martin Esteban, Samuel; Mostany, Ricardo; Garcia-Caceres, Cristina; Tschöp, Matthias; Iglesias, Teresa; de Ceballos, Maria L; Gutierrez, Antonia; Torres Aleman, Ignacio
Abstract:
Mice with insulin receptor (IR)-deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted responses to insulin and reduced brain glucose uptake, whereas IR-deficient astrocytes show disturbed mitochondrial responses to glucose. While exploring the functional impact of disturbed mitochondrial function in astrocytes, we observed that GFAP-IR KO mice show uncoupling of brain blood flow with glucose uptake. Since IR-deficient astrocytes show higher levels of reactive oxidant species (ROS), this...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2022
Journal volume:
119
Journal issue:
29
Fulltext / DOI:
doi:10.1073/pnas.2204527119
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35858325
Print-ISSN:
0027-8424
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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