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Title:

Platelet Surface Protein Expression and Reactivity upon TRAP Stimulation after BNT162b2 Vaccination.

Document type:
Article; Journal Article
Author(s):
Klug, Melissa; Lazareva, Olga; Kirmes, Kilian; Rosenbaum, Marc; Lukas, Marina; Weidlich, Simon; Spinner, Christoph D; von Scheidt, Moritz; Gosetti, Rosanna; Baumbach, Jan; Ruland, Jürgen; Condorelli, Gianluigi; Laugwitz, Karl-Ludwig; List, Markus; Bernlochner, Isabell; Bongiovanni, Dario
Abstract:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a coagulopathy characterized by platelet activation and a hypercoagulable state with an increased incidence of cardiovascular events. The viral spike protein S has been reported to enhance thrombosis formation, stimulate platelets to release procoagulant factors, and promote the formation of platelet-leukocyte aggregates even in absence of the virus. Although SARS-CoV-2 vaccines induce spike protein overexpression to...     »
Journal title abbreviation:
Thromb Haemost
Year:
2022
Journal volume:
122
Journal issue:
10
Pages contribution:
1706-1711
Fulltext / DOI:
doi:10.1055/s-0041-1733934
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34388849
Print-ISSN:
0340-6245
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert); Klinik und Poliklinik für Innere Medizin I, Kardiologie; Klinik und Poliklinik für Innere Medizin II, Gastroenterologie
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