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Title:

Partial-Brain Radiation-Induced Microvascular Cognitive Impairment in Juvenile Murine Unilateral Hippocampal Synaptic Plasticity.

Document type:
Journal Article
Author(s):
Fan, Hengyi; Sievert, Wolfgang; Hofmann, Julian; Keppler, Selina J; Steiger, Katja; Puig-Bosch, Xènia; Haller, Bernhard; Rammes, Gerhard; Multhoff, Gabriele
Abstract:
PURPOSE: Radiation-induced cognitive deficits have a severe negative impact on pediatric brain tumor patients. The severity of cognitive symptoms is related to the age of the child when radiation was applied, with the most severe effects seen in the youngest. Previous studies using whole-brain irradiation in mice confirmed these findings. To understand ipsilateral and contralateral changes in the hippocampus after partial-brain radiation therapy (PBRT) of the left hemisphere, we assessed the neu...     »
Journal title abbreviation:
Int J Radiat Oncol Biol Phys
Year:
2022
Journal volume:
112
Journal issue:
3
Pages contribution:
747-758
Fulltext / DOI:
doi:10.1016/j.ijrobp.2021.09.041
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34619330
Print-ISSN:
0360-3016
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für KI und Informatik in der Medizin (Prof. Rückert); Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland); Klinik für Anästhesiologie (DHM); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs); Lehrstuhl für Medizinische Informatik (Prof. Boeker)
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