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Title:

MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Rosenbaum, Marc; Schnalzger, Theresa; Engleitner, Thomas; Weiß, Christin; Mishra, Ritu; Mibus, Cora; Mitterer, Theresa; Rad, Roland; Ruland, Jürgen
Abstract:
Regulatory T cells (Tregs) are essential for the inhibition of immunity and the maintenance of tissue homeostasis. Signals from the T-cell antigen receptor (TCR) are critical for early Treg development, their expansion, and inhibitory activity. Although TCR-engaged activation of the paracaspase MALT1 is important for these Treg activities, the MALT1 effector pathways in Tregs remain ill-defined. Here, we demonstrate that MALT1 protease activity controls the TCR-induced upregulation of the transc...     »
Journal title abbreviation:
Eur J Immunol
Year:
2022
Journal volume:
52
Journal issue:
1
Pages contribution:
85-95
Fulltext / DOI:
doi:10.1002/eji.202149355
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34668583
Print-ISSN:
0014-2980
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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