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Title:

Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Landspersky, Theresa; Saçma, Mehmet; Rivière, Jennifer; Hecker, Judith S; Hettler, Franziska; Hameister, Erik; Brandstetter, Katharina; Istvánffy, Rouzanna; Romero Marquez, Sandra; Ludwig, Romina; Götz, Marilena; Buck, Michèle; Wolf, Martin; Schiemann, Matthias; Ruland, Jürgen; Strunk, Dirk; Shimamura, Akiko; Myers, Kasiani; Yamaguchi, Terry P; Kieslinger, Matthias; Leonhardt, Heinrich; Bassermann, Florian; Götze, Katharina S; Geiger, Hartmut; Schreck, Christina; Oostendorp, Robert A J
Abstract:
The cellular mechanisms required to ensure homeostasis of the hematopoietic niche and the ability of this niche to support hematopoiesis upon stress remain elusive. We here identify Wnt5a in Osterix+ mesenchymal progenitor and stem cells (MSPCs) as a critical factor for niche-dependent hematopoiesis. Mice lacking Wnt5a in MSPCs suffer from stress-related bone marrow (BM) failure and increased mortality. Niche cells devoid of Wnt5a show defective actin stress fiber orientation due to an elevated...     »
Journal title abbreviation:
Blood
Year:
2022
Journal volume:
139
Journal issue:
5
Pages contribution:
690-703
Fulltext / DOI:
doi:10.1182/blood.2021011775
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34657154
Print-ISSN:
0006-4971
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie
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