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Titel:

The molecular ontogeny of follicular lymphoma: gene mutations succeeding the BCL2 translocation define common precursor cells.

Dokumenttyp:
Journal Article
Autor(en):
Haebe, Sarah; Keay, William; Alig, Stefan; Mohr, Anne-Wiebe; Martin, Larissa K; Heide, Michael; Secci, Ramona; Krebs, Stefan; Blum, Helmut; Moosmann, Andreas; Louissaint, Abner; Weinstock, David M; Thoene, Silvia; von Bergwelt-Baildon, Michael; Ruland, Jürgen; Bararia, Deepak; Weigert, Oliver
Abstract:
Relapsed follicular lymphoma (FL) can arise from common progenitor cells (CPCs). Conceptually, CPC-defining mutations are somatic alterations shared by the initial and relapsed tumours, mostly B-cell leukaemia/lymphoma 2 (BCL2)/immunoglobulin heavy locus (IGH) translocations and other recurrent gene mutations. Through complementary approaches for highly sensitive mutation detection, we do not find CPC-defining mutations in highly purified BCL2/IGH-negative haematopoietic progenitor cells in clin...     »
Zeitschriftentitel:
Br J Haematol
Jahr:
2022
Band / Volume:
196
Heft / Issue:
6
Seitenangaben Beitrag:
1381-1387
Volltext / DOI:
doi:10.1111/bjh.17990
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34967008
Print-ISSN:
0007-1048
TUM Einrichtung:
608; Institut für Klinische Chemie und Pathobiochemie
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