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- Title:
Complete Atrioventricular Septal Defects after the Age of 40 Years.
- Document type:
- Article; Journal Article
- Author(s):
- Maurer, Susanne J; Moosholzer, Lorena; Pujol, Claudia; Nagdyman, Nicole; Ewert, Peter; Tutarel, Oktay
- Abstract:
- BACKGROUND: There is an increasing number of adults with complete atrioventricular septal defects (cAVSD). However, data regarding older adults are lacking. The aim of this study is to analyze the outcome of adults with cAVSD over the age of 40 years. METHODS: Patients with cAVSD who were ≥40 years of age at any point between 2005 until 2018 were included retrospectively. Data were retrieved from hospital records. The primary endpoint was a combination of death from any cause and unplanned hospitalizations due to cardiac reasons. RESULTS: 43 patients (60.5% female, mean age 43.7 ± 6.0 years, genetic syndrome 58.1%) were included. At begin of follow-up, the majority of patients (n = 41, 95.3%) was in New York Heart Association (NYHA) class I or II. Out of the whole cohort 26 (60.5%) had undergone cardiac surgery. At baseline, at least one extracardiac comorbidity was present in 40 patients (93.0%). Median follow-up was 1.7 years (IQR 0.3-4.6). On univariate Cox analysis, NYHA class at begin of follow-up (hazard ratio: 1.96, CI 95%: 1.04-3.72, p < 0.05) was the only predictor for the primary endpoint. CONCLUSIONS: Significant morbidity and mortality is present in cAVSD patients over the age of 40 years. NYHA class is predictive for a worse outcome.
- Journal title abbreviation:
- J Clin Med
- Year:
- 2021
- Journal volume:
- 10
- Journal issue:
- 16
- Fulltext / DOI:
- doi:10.3390/jcm10163665
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/34441962
- TUM Institution:
- Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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