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Title:

In vivo visualization and molecular targeting of the cardiac conduction system.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Author(s):
Goodyer, William R; Beyersdorf, Benjamin M; Duan, Lauren; van den Berg, Nynke S; Mantri, Sruthi; Galdos, Francisco X; Puluca, Nazan; Buikema, Jan W; Lee, Soah; Salmi, Darren; Robinson, Elise R; Rogalla, Stephan; Cogan, Dillon P; Khosla, Chaitan; Rosenthal, Eben L; Wu, Sean M
Abstract:
Accidental injury to the cardiac conduction system (CCS), a network of specialized cells embedded within the heart and indistinguishable from the surrounding heart muscle tissue, is a major complication in cardiac surgeries. Here, we addressed this unmet need by engineering targeted antibody-dye conjugates directed against the CCS, allowing for the visualization of the CCS in vivo following a single intravenous injection in mice. These optical imaging tools showed high sensitivity, specificity,...     »
Journal title abbreviation:
J Clin Invest
Year:
2022
Journal volume:
132
Journal issue:
20
Fulltext / DOI:
doi:10.1172/JCI156955
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35951416
Print-ISSN:
0021-9738
TUM Institution:
Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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