Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions.

Thakur, Kiran T; Tamborska, Arina; Wood, Greta K; McNeill, Emily; Roh, David; Akpan, Imo J; Miller, Eliza C; Bautista, Alyssa; Claassen, Jan; Kim, Carla Y; Guekht, Alla; Pardo, Carlos A; Williams, Olajide; García-Azorín, David; Prasad, Kameshwar; Schmutzhard, Erich; Michael, Benedict D; Chou, Sherry H-Y; Winkler, Andrea S; Solomon, Tom; Elkind, Mitchell S

doi:10.1016/j.jns.2021.117532

journal article

Title:: Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions.
Document type:: Review; Journal Article; Review
Author(s):: Thakur, Kiran T; Tamborska, Arina; Wood, Greta K; McNeill, Emily; Roh, David; Akpan, Imo J; Miller, Eliza C; Bautista, Alyssa; Claassen, Jan; Kim, Carla Y; Guekht, Alla; Pardo, Carlos A; Williams, Olajide; García-Azorín, David; Prasad, Kameshwar; Schmutzhard, Erich; Michael, Benedict D; Chou, Sherry H-Y; Winkler, Andrea S; Solomon, Tom; Elkind, Mitchell S
Abstract:: BACKGROUND: Vaccine induced immune mediated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2·S Johnson and Johnson (Janssen/J&J). The evaluation and management of suspected cases of CVT post COVID-19 vaccination are critical skills for a broad range of healthcare providers. METHODS: A collaborative comprehensive review of literature was conducted among a global group of expert neurologists and hematologists. FINDINGS: Strategies for rapid evaluation and treatment of the CVT in the context of possible VITT exist, including inflammatory marker measurements, PF4 assays, and non-heparin anticoagulation. «
BACKGROUND: Vaccine induced immune mediated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2·S Johnson and Johnson (Janssen/J&J;). The evaluation and management of suspected cases of CVT post COVID-19 vaccination are critical skills for a broad range of healthcare providers. METHODS: A... »
Journal title abbreviation:: J Neurol Sci
Year:: 2021
Journal volume:: 427
Fulltext / DOI:: doi:10.1016/j.jns.2021.117532
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/34134058
Print-ISSN:: 0022-510X
TUM Institution:: Neurologische Klinik und Poliklinik
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Neurologie (Prof. Hemmer)2021