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Title:

Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Author(s):
Eroglu, Elif; Yen, Christopher Y T; Tsoi, Yat-Long; Witman, Nevin; Elewa, Ahmed; Joven Araus, Alberto; Wang, Heng; Szattler, Tamara; Umeano, Chimezie H; Sohlmér, Jesper; Goedel, Alexander; Simon, András; Chien, Kenneth R
Abstract:
The contribution of the epicardium, the outermost layer of the heart, to cardiac regeneration has remained controversial due to a lack of suitable analytical tools. By combining genetic marker-independent lineage-tracing strategies with transcriptional profiling and loss-of-function methods, we report here that the epicardium of the highly regenerative salamander species Pleurodeles waltl has an intrinsic capacity to differentiate into cardiomyocytes. Following cryoinjury, CLDN6+ epicardium-deri...     »
Journal title abbreviation:
Nat Cell Biol
Year:
2022
Journal volume:
24
Journal issue:
5
Pages contribution:
645-658
Fulltext / DOI:
doi:10.1038/s41556-022-00902-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35550612
Print-ISSN:
1465-7392
TUM Institution:
Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
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